Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 18/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21129936 | 0.86 | NNMT (0.37) | NNMTPRMT5WDR77 | |
| SCHEMBL24595470 | 0.82 | PRMT5 (0.35) | NNMTPRMT5WDR77 | |
| SCHEMBL24067745 | 0.77 | NNMT (0.38) | NNMTPRMT5WDR77 | |
| SCHEMBL10248595 | 0.76 | NNMT (0.41) | NNMTPRMT5WDR77 | |
| SCHEMBL25049137 | 0.75 | NNMT (0.36) | NNMTPRMT5WDR77 | |
| SCHEMBL21312896 | 0.75 | PRMT5 (0.36) | NNMTPRMT5WDR77 | |
| SCHEMBL22521583 | 0.74 | HTR2B (0.36) | PRMT5WDR77 | |
| SCHEMBL9469927 | 0.74 | NNMT (0.42) | NNMTPRMT5WDR77 | |
| SCHEMBL24090740 | 0.74 | PRMT5 (0.40) | NNMTPRMT5WDR77 | |
| SCHEMBL22002025 | 0.73 | AHCY (0.52) | NNMTPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724190-B1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LTD (IN) | 2022-07-06 | — | — | EP | disclosed |
| WO-2020250123-A1 | PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2020-12-17 | — | — | WO | disclosed |
| WO-2019116302-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2019-06-20 | — | — | WO | disclosed |