Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 8/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | VEGFA | P15692 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1129736 | 0.95 | HDAC3 (0.40) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL23863507 | 0.84 | HDAC3 (0.41) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL21595152 | 0.78 | HDAC3 (0.39) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL608253 | 0.78 | CNR2 (0.43) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL12263459 | 0.74 | HTR2C (0.44) | ALDH1A1MAPTNPC1 | |
| SCHEMBL12859678 | 0.74 | PARP1 (0.40) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1130229 | 0.74 | PKM (0.46) | ADORA2BVEGFAEGLN1MAPTCNR1 | |
| SCHEMBL1441164 | 0.73 | ALDH1A1 (0.40) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL16899407 | 0.73 | MAPK14 (0.53) | HDAC8HDAC6VEGFAEGLN1ALDH1A1 | |
| SCHEMBL7459341 | 0.72 | L3MBTL1 (0.54) | ADORA2BTSHRRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689640-B | Compounds useful as immunomodulators | 百时美施贵宝公司 | 2022-01-04 | — | — | CN | disclosed |
| EP-3481815-B1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2021-09-29 | — | — | EP | disclosed |
| US-10590105-B2 | 1,3-dihydroxy-phenyl derivatives useful as immunomodulators | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2020-03-17 | — | — | US | disclosed |
| US-20190185450-A1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190185450-A1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | CD74, CD2, HAVCR2 | HDAC3 2713/4885HDAC4 2917/4885HDAC1 1355/4885 |
| US-10590105-B2 | 1,3-dihydroxy-phenyl derivatives useful as immunomodulators | CD74, CD2, HAVCR2 | HDAC3 2713/4885HDAC4 2917/4885HDAC1 1355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.