Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211967 | 1.00 | USP2 (0.45) | USP2SLCO1B1TRPV1TRPA1CYP2D6 | |
| SCHEMBL8746986 | 0.91 | USP2 (0.48) | USP2SLCO1B1TRPV1TRPA1CYP2D6 | |
| SCHEMBL5167211 | 0.82 | USP2 (0.52) | USP2SLCO1B1LMNABLMCYP1A2 | |
| SCHEMBL25193896 | 0.82 | GPR84 (0.59) | CYP2D6SPHK1GMNNLMNAPOLB | |
| SCHEMBL21853754 | 0.82 | GPR84 (0.59) | CYP2D6SPHK1GMNNLMNAPOLB | |
| SCHEMBL11115743 | 0.82 | GPR84 (0.59) | CYP2D6SPHK1GMNNLMNAPOLB | |
| SCHEMBL25266087 | 0.82 | GPR84 (0.59) | CYP2D6SPHK1GMNNLMNAPOLB | |
| SCHEMBL497548 | 0.82 | GPR84 (0.59) | CYP2D6SPHK1GMNNLMNAPOLB | |
| SCHEMBL11121661 | 0.82 | GPR84 (0.59) | CYP2D6SPHK1GMNNLMNAPOLB | |
| SCHEMBL19132466 | 0.82 | GPR84 (0.59) | CYP2D6SPHK1GMNNLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |