Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 3/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24716791 | 1.00 | NR1H2 (0.58) | NR1H2HPGDUSP2SMN1; SMN2PREP | |
| SCHEMBL18970274 | 1.00 | NR1H2 (0.58) | NR1H2HPGDUSP2SMN1; SMN2PREP | |
| SCHEMBL21949853 | 1.00 | NR1H2 (0.58) | NR1H2HPGDUSP2SMN1; SMN2PREP | |
| SCHEMBL13698857 | 0.93 | NR1H2 (0.55) | NR1H2HPGDUSP2SMN1; SMN2PREP | |
| SCHEMBL13698847 | 0.93 | NR1H2 (0.55) | NR1H2HPGDUSP2SMN1; SMN2PREP | |
| SCHEMBL23906106 | 0.90 | NR1H2 (0.64) | NR1H2HPGDUSP2SMN1; SMN2PREP | |
| SCHEMBL24718097 | 0.89 | NR1H2 (0.63) | NR1H2HPGDUSP2SMN1; SMN2PREP | |
| SCHEMBL16307878 | 0.86 | NR1H2 (0.55) | NR1H2HPGDUSP2SMN1; SMN2GPR119 | |
| SCHEMBL24751957 | 0.85 | NR1H2 (0.58) | NR1H2HPGDUSP2SMN1; SMN2PREP | |
| SCHEMBL10106246 | 0.85 | NR1H2 (0.58) | NR1H2HPGDUSP2SMN1; SMN2PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10336748-B2 | Methyoxy-substituted pyrrolopyridine modulators of RORC2 and methods of use thereof | PFIZER INC. (US) | 2019-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336748-B2 | Methyoxy-substituted pyrrolopyridine modulators of RORC2 and methods of use thereof | RORC, RORB, RORA | NR1H2 13/4885HPGD 398/4885USP2 3144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.