Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.37 |
| ▸ | NOS1 | P29475 | 2/20 | 0.37 |
| ▸ | METAP2 | P50579 | 2/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 3/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.34 |
| ▸ | AURKA | O14965 | 3/20 | 0.34 |
| ▸ | XDH | P47989 | 2/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | PAK4 | O96013 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2113624 | 0.87 | XDH (0.42) | NOS1MKNK1MAPK1CHEK1CHEK2 | |
| SCHEMBL10329 | 0.82 | DYRK1A (0.50) | DYRK1ANOS1METAP2CSNK2A1MKNK1 | |
| SCHEMBL29487975 | 0.70 | DYRK1A (0.39) | DYRK1ANOS1METAP2CSNK2A1MAPK1 | |
| SCHEMBL15577658 | 0.68 | NOS1 (0.53) | DYRK1ANOS1METAP2CSNK2A1MKNK1 | |
| SCHEMBL20176622 | 0.68 | XDH (0.44) | NOS1MKNK1MAPK1CHEK1RET | |
| SCHEMBL9940746 | 0.67 | NOS1 (0.55) | DYRK1ANOS1METAP2CSNK2A1MAPK1 | |
| SCHEMBL31555833 | 0.65 | PLK4 (0.41) | DYRK1ANOS1METAP2CSNK2A1CHEK1 | |
| SCHEMBL16537147 | 0.65 | DYRK1B (0.44) | DYRK1ACSNK2A1CHEK1RETLRRK2 | |
| SCHEMBL21856831 | 0.64 | AXL (0.41) | DYRK1ANOS1METAP2CSNK2A1CHEK1 | |
| SCHEMBL20674185 | 0.63 | FGFR1 (0.40) | DYRK1ACSNK2A1MAPK1CHEK1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158647-B2 | Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2012-04-17 | — | — | US | disclosed |