Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 8/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.39 |
| ▸ | AURKA | O14965 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | FLT1 | P17948 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | CLK2 | P49760 | 3/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.39 |
| ▸ | PAK4 | O96013 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.39 |
| ▸ | LTK | P29376 | 2/20 | 0.39 |
| ▸ | GRK5 | P34947 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10329 | 0.81 | DYRK1A (0.50) | DYRK1ADYRK1BAURKAJAK2MAP4K4 | |
| SCHEMBL2113605 | 0.70 | DYRK1A (0.37) | DYRK1ADYRK1BAURKAJAK2MAP4K4 | |
| SCHEMBL1500697 | 0.68 | SMN1; SMN2 (0.48) | DYRK1ADYRK1BAURKAJAK2MAP4K4 | |
| SCHEMBL15577658 | 0.67 | NOS1 (0.53) | DYRK1AJAK2KDRAURKBRET | |
| SCHEMBL153413 | 0.65 | CDK8 (0.55) | DYRK1ADYRK1BJAK2MAP4K4FGFR1 | |
| SCHEMBL30008611 | 0.65 | — | — | |
| SCHEMBL15750978 | 0.64 | DYRK1A (0.43) | DYRK1ADYRK1BAURKAJAK2MAP4K4 | |
| SCHEMBL2038921 | 0.64 | BRD4 (0.47) | DYRK1ADYRK1BAURKAJAK2MAP4K4 | |
| SCHEMBL20004649 | 0.64 | DYRK1A (0.43) | DYRK1ADYRK1BAURKAJAK2MAP4K4 | |
| Magnesium SCHEMBL30992114 | 0.64 | CDK8 (0.53) | DYRK1ADYRK1BJAK2MAP4K4FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3619205-B1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV HEALTHCARE UK NO 5 LTD (GB) | 2022-04-06 | — | — | EP | disclosed |