Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PPIA | P62937 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21136934 | 0.85 | MAPT (0.41) | PGK1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL26131871 | 0.82 | CYP1A2 (0.37) | MAPTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL29969235 | 0.82 | CYP1A2 (0.37) | MAPTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL23615879 | 0.82 | PGK1 (0.42) | PGK1MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL21050688 | 0.82 | MAPT (0.37) | PGK1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL4712057 | 0.82 | EGFR (0.39) | PGK1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL21050767 | 0.79 | MAPT (0.37) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1024702 | 0.79 | MAPT (0.47) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL11980661 | 0.79 | ERN1 (0.40) | NR1H4CYP2C9 | |
| SCHEMBL246700 | 0.78 | PDGFRB (0.49) | MAPTALDH1A1TDP1EGFRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |