Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 2/20 | 0.38 |
| ▸ | SKP1 | P63208 | 2/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21136729 | 0.87 | GPR119 (0.41) | GPR119KCNH2MAP4K4KITCKS1B | |
| SCHEMBL27094365 | 0.86 | MAP4K4 (0.42) | GPR119KCNH2MAP4K4SMARCA2SMARCA4 | |
| SCHEMBL16647196 | 0.81 | KIT (0.52) | GPR119KCNH2MAP4K4SMARCA2SMARCA4 | |
| SCHEMBL16636974 | 0.79 | MAPK8 (0.39) | GPR119KCNH2MAP4K4RETKIT | |
| SCHEMBL16636900 | 0.78 | MAPK8 (0.39) | GPR119KCNH2RETKITPTPN11 | |
| SCHEMBL25333920 | 0.77 | GBA1 (0.44) | GPR119KCNH2MAP4K4KITCKS1B | |
| SCHEMBL21136735 | 0.77 | KCNH2 (0.47) | GPR119KCNH2CKS1BSKP1SKP2 | |
| SCHEMBL20570346 | 0.77 | NR1H2 (0.46) | GPR119KCNH2RET | |
| SCHEMBL21136722 | 0.76 | MAP4K4 (0.42) | GPR119KCNH2MAP4K4SMARCA2SMARCA4 | |
| SCHEMBL21136711 | 0.75 | MAPK8 (0.41) | GPR119KCNH2KITALKMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |