Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | CCND3 | P30281 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCND2 | P30279 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 3/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21137118 | 0.84 | KCNH2 (0.40) | KCNH2GPR119MEN1MAPTTSHR | |
| SCHEMBL21137556 | 0.83 | GPR119 (0.41) | KCNH2GPR119MEN1MAPTTSHR | |
| SCHEMBL21136711 | 0.83 | MAPK8 (0.41) | KCNH2GPR119MEN1MAPTTSHR | |
| SCHEMBL21137523 | 0.74 | SUV39H2 (0.44) | KCNH2GPR119MEN1MAPTTSHR | |
| SCHEMBL21136729 | 0.74 | GPR119 (0.41) | KCNH2GPR119MEN1MAPTTSHR | |
| SCHEMBL21099382 | 0.70 | KRAS (0.43) | GPR119 | |
| SCHEMBL21137563 | 0.69 | CKS1B (0.38) | KCNH2GPR119MEN1MAPTTSHR | |
| SCHEMBL24847099 | 0.68 | LMNA (0.48) | KCNH2GPR119MEN1MAPTKMT2A | |
| SCHEMBL22322207 | 0.67 | CKS1B (0.49) | GPR119MEN1MAPTTSHRKMT2A | |
| SCHEMBL30983945 | 0.67 | CKS1B (0.49) | GPR119MEN1MAPTTSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |