Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.65 |
| ▸ | HSD17B3 | P37058 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | THPO | P40225 | 2/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.49 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11321458 | 0.82 | HSD17B3 (0.60) | HSD17B3SMN1; SMN2ALDH1A1MAPTTSHR | |
| SCHEMBL8193682 | 0.80 | EGFR (0.69) | EGFRERBB2SMN1; SMN2ALDH1A1HIF1A | |
| SCHEMBL11980711 | 0.79 | EGFR (0.63) | EGFRERBB2SMN1; SMN2ALDH1A1HIF1A | |
| SCHEMBL2113387 | 0.78 | HDAC6 (0.68) | EGFRERBB2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2115806 | 0.78 | EGFR (0.54) | EGFRERBB2SMN1; SMN2ALDH1A1HIF1A | |
| SCHEMBL26254861 | 0.78 | HSD17B3 (0.82) | HSD17B3SMN1; SMN2ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL10345229 | 0.77 | HSD17B3 (0.62) | HSD17B3SMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL766052 | 0.77 | EGFR (0.61) | EGFRERBB2SMN1; SMN2ALDH1A1HIF1A | |
| SCHEMBL7462603 | 0.77 | EGFR (0.60) | EGFRERBB2SMN1; SMN2ALDH1A1HIF1A | |
| Butyric Acid SCHEMBL7166690 | 0.77 | EGFR (0.57) | EGFRERBB2SMN1; SMN2ALDH1A1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552176-B2 | Glycosylated chlorambucil analogs and uses thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-10-08 | — | — | US | disclosed |
| US-20120094946-A1 | GLYCOSYLATED CHLORAMBUCIL ANALOGS AND USES THEREOF | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094946-A1 | GLYCOSYLATED CHLORAMBUCIL ANALOGS AND USES THEREOF | CD22, UGGT1, UGCG | EGFR 1475/4885ERBB2 1132/4885HSD17B3 4439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.