Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 3/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2114300 | 0.82 | CHRM1 (0.35) | CHRM1CHRM2CHRM4NAMPTMEN1 | |
| SCHEMBL2113831 | 0.81 | NR1H2 (0.41) | CHRM1CHRM2CHRM4MEN1ALDH1A1 | |
| SCHEMBL4651408 | 0.81 | NR1H2 (0.41) | CHRM1CHRM2CHRM4MEN1ALDH1A1 | |
| SCHEMBL4651411 | 0.81 | NR1H2 (0.41) | CHRM1CHRM2CHRM4MEN1ALDH1A1 | |
| SCHEMBL5121326 | 0.81 | NR1H2 (0.41) | CHRM1CHRM2CHRM4MEN1ALDH1A1 | |
| SCHEMBL4868985 | 0.81 | CHRM1 (0.53) | CHRM1CHRM2CHRM4NAMPTMEN1 | |
| SCHEMBL4868987 | 0.81 | CHRM1 (0.53) | CHRM1CHRM2CHRM4NAMPTMEN1 | |
| SCHEMBL4870913 | 0.81 | CHRM1 (0.53) | CHRM1CHRM2CHRM4NAMPTMEN1 | |
| SCHEMBL5115602 | 0.80 | CHRM1 (0.56) | CHRM1CHRM2CHRM4NAMPT | |
| SCHEMBL4868636 | 0.80 | CHRM1 (0.56) | CHRM1CHRM2CHRM4NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227468-B2 | Cathepsin S inhibitor compounds | ELI LILLY AND COMPANY (US) | 2012-07-24 | — | — | US | disclosed |
| US-20120095020-A1 | Cathepsin S Inhibitor Compounds | ELI LILLY AND COMPANY (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095020-A1 | Cathepsin S Inhibitor Compounds | CTSS, CTSZ, CTSV | CHRM1 4241/4885CHRM2 4275/4885CHRM4 4744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.