Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5804112 | 0.77 | KMT2A (0.44) | KMT2AALDH1A1MEN1MAPTTDP1 | |
| SCHEMBL15942167 | 0.75 | KMT2A (0.45) | KMT2AALDH1A1MEN1MAPTTDP1 | |
| SCHEMBL18189083 | 0.75 | ALDH1A1 (0.45) | KMT2AALDH1A1MEN1MAPTKDM4E | |
| SCHEMBL18189084 | 0.75 | ALDH1A1 (0.45) | KMT2AALDH1A1MEN1MAPTKDM4E | |
| SCHEMBL525254 | 0.72 | — | — | |
| SCHEMBL18189010 | 0.72 | GPR52 (0.50) | KMT2AALDH1A1MEN1POLBPKM | |
| SCHEMBL18189011 | 0.72 | GPR52 (0.50) | KMT2AALDH1A1MEN1POLBPKM | |
| SCHEMBL21140376 | 0.72 | TDP1 (0.48) | KMT2AMAPTTDP1POLBHCAR2 | |
| SCHEMBL5319337 | 0.71 | KMT2A (0.67) | KMT2AALDH1A1MEN1MAPTTDP1 | |
| Urea SCHEMBL17075255 | 0.70 | KMT2A (0.50) | KMT2AALDH1A1MEN1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11220513-B2 | Chromium-mediated coupling and application to the synthesis of halichondrins | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-01-11 | — | — | US | disclosed |
| US-20210009605-A1 | CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-01-14 | — | — | US | disclosed |
| US-10633392-B2 | Chromium-mediated coupling and application to the synthesis of halichondrins | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-04-28 | — | — | US | disclosed |
| US-20200031843-A1 | CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-01-30 | — | — | US | disclosed |
| US-10344038-B2 | Chromium-mediated coupling and application to the synthesis of halichondrins | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11220513-B2 | Chromium-mediated coupling and application to the synthesis of halichondrins | CROCC, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, KAT7 | KMT2A 718/4885ALDH1A1 999/4885MEN1 721/4885 |
| US-10344038-B2 | Chromium-mediated coupling and application to the synthesis of halichondrins | CA9, CROCC, CHD9 | KMT2A 861/4885ALDH1A1 998/4885MEN1 2126/4885 |
| US-20210009605-A1 | CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS | CROCC, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, KAT7 | KMT2A 718/4885ALDH1A1 999/4885MEN1 721/4885 |
| US-10633392-B2 | Chromium-mediated coupling and application to the synthesis of halichondrins | CA9, CROCC, CHD9 | KMT2A 861/4885ALDH1A1 998/4885MEN1 2126/4885 |
| US-20200031843-A1 | CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS | CROCC, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, KAT7 | KMT2A 718/4885ALDH1A1 999/4885MEN1 721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.