Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.42 |
| ▸ | SRC | P12931 | 3/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 5/20 | 0.40 |
| ▸ | RET | P07949 | 4/20 | 0.40 |
| ▸ | FLT3 | P36888 | 4/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.40 |
| ▸ | STK3 | Q13188 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | CSF1R | P07333 | 3/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.40 |
| ▸ | FLT4 | P35916 | 3/20 | 0.40 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2114542 | 0.91 | PDGFRB (0.45) | KDRFGFR1PDGFRBSRCFLT3 | |
| SCHEMBL2117426 | 0.89 | PDGFRB (0.45) | KDRFGFR1PDGFRBSRCRET | |
| SCHEMBL2117434 | 0.88 | RET (0.44) | KDRFGFR1PDGFRBSRCPIM1 | |
| SCHEMBL2115632 | 0.88 | KDR (0.45) | KDRFGFR1PDGFRBSRCFLT3 | |
| SCHEMBL2117534 | 0.74 | CCNB2 (0.42) | KDRFGFR1PDGFRBSRCRET | |
| SCHEMBL2116290 | 0.74 | LRRK2 (0.41) | KDRFGFR1PDGFRBSRCRET | |
| SCHEMBL2113982 | 0.74 | KDR (0.47) | KDRFGFR1PDGFRBSRCFLT3 | |
| SCHEMBL2114046 | 0.73 | PDGFRB (0.45) | KDRFGFR1PDGFRBSRCRET | |
| SCHEMBL2113729 | 0.73 | PDGFRB (0.43) | KDRFGFR1PDGFRBSRCRET | |
| SCHEMBL2116323 | 0.72 | KDR (0.45) | KDRFGFR1PDGFRBSRCRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | NEKTAR THERAPEUTICS (US) | 2012-04-19 | — | — | US | disclosed |
| US-7125905-B2 | Pyrrole substituted 2-indolinone protein kinase inhibitors | AGOURON PHARMACEUTICALS, INC. (US) | 2006-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | PTK2B, ERBB2, FRK | KDR 395/4885FGFR1 462/4885PDGFRB 555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.