Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 7/20 | 0.44 |
| ▸ | KDR | P35968 | 5/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.41 |
| ▸ | SYK | P43405 | 4/20 | 0.41 |
| ▸ | FCER2 | P06734 | 1/20 | 0.41 |
| ▸ | TLK2 | Q86UE8 | 4/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 3/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | CDK7 | P50613 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2115632 | 0.94 | KDR (0.45) | KDRTLK2SRCAURKAFGFR1 | |
| SCHEMBL2117426 | 0.89 | PDGFRB (0.45) | RETKDRSRCCDK1PLK4 | |
| SCHEMBL2114178 | 0.88 | KDR (0.42) | RETKDRSYKPDPK1SRC | |
| SCHEMBL2114542 | 0.82 | PDGFRB (0.45) | KDRSRCCDK2CHEK1FGFR1 | |
| SCHEMBL2114046 | 0.74 | PDGFRB (0.45) | RETKDRSRCCDK1PLK4 | |
| SCHEMBL2113729 | 0.73 | PDGFRB (0.43) | RETKDRSRCCDK1PLK4 | |
| SCHEMBL2116323 | 0.72 | KDR (0.45) | RETKDRSRCCDK1PLK4 | |
| SCHEMBL2117534 | 0.71 | CCNB2 (0.42) | RETKDRTLK2SRCCDK1 | |
| SCHEMBL2116290 | 0.71 | LRRK2 (0.41) | RETKDRLRRK2SRCCDK1 | |
| SCHEMBL2117973 | 0.69 | PDGFRB (0.42) | RETKDRLRRK2SRCCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | NEKTAR THERAPEUTICS (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | PTK2B, ERBB2, FRK | RET 73/4885KDR 395/4885LRRK2 580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.