SCHEMBL2114379

SCHEMBL2114379

CC[Si](CC)(CC)c1ccc(Cc2ccc([Si](CC)(CC)CC)cc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 2/20 0.45
NR1H3 Q13133 2/20 0.45
ALDH1A1 P00352 5/20 0.40
CYP3A4 P08684 4/20 0.40
TSHR P16473 3/20 0.40
TDP1 Q9NUW8 2/20 0.40
MAPK1 P28482 1/20 0.40
ESR1 P03372 2/20 0.39
ESR2 Q92731 1/20 0.39
KMT2A Q03164 2/20 0.37
HPGD P15428 4/20 0.37
LMNA P02545 3/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
HTT P42858 2/20 0.37
CALM1 P0DP23 1/20 0.36
LTA4H P09960 1/20 0.34
MAPT P10636 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
KDM4E B2RXH2 2/20 0.33
CYP17A1 P05093 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7056361 0.85 NR1H2 (0.54) NR1H2NR1H3ESR1ESR2
SCHEMBL988371 0.74 ACHE (0.47) NR1H2NR1H3ALDH1A1TSHRTDP1
SCHEMBL9243328 0.72 NR1H2 (0.45) NR1H2NR1H3ALDH1A1CYP3A4TSHR
SCHEMBL3026782 0.72 NR1H2 (0.45) NR1H2NR1H3ALDH1A1MAPK1ESR1
SCHEMBL9183006 0.72 NR1H2 (0.45) NR1H2NR1H3ALDH1A1CYP3A4TSHR
SCHEMBL23190380 0.72 NR1H2 (0.50) NR1H2NR1H3ESR1KMT2ALMNA
SCHEMBL2168523 0.72 NR1H2 (0.45) NR1H2NR1H3ESR1ESR2
SCHEMBL14437782 0.72 NR1H2 (0.45) NR1H2NR1H3ESR1ESR2
SCHEMBL16537645 0.72 ESR1 (0.68) NR1H2NR1H3ALDH1A1CYP3A4TSHR
SCHEMBL27980976 0.72 NR1H2 (0.45) NR1H2NR1H3ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8957159-B2 Multiple catalyst system for olefin polymerization and polymers produced therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2015-02-17 US disclosed
US-20140066567-A1 Multiple Catalyst System for Olefin Polymerization and Polymers Produced Therefrom EXXONMOBIL CHEMICAL PATENTS INC. 2014-03-06 US disclosed
US-8563647-B2 Multiple catalyst system for olefin polymerization and polymers produced therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2013-10-22 US disclosed
EP-1558655-B1 MULTIPLE CATALYST SYSTEM FOR OLEFIN POLYMERIZATION AND POLYMERS PRODUCED THEREFROM EXXONMOBIL CHEM PATENTS INC (US) 2012-08-29 EP disclosed
US-20120095157-A1 Multiple Catalyst System For Olefin Polymerization And Polymers Produced Therefrom EXXONMOBIL CHEMICAL PATENTS INC. 2012-04-19 US disclosed
EP-1753796-B1 MULTIPLE CATALYST AND REACTOR SYSTEM FOR OLEFIN POLYMERIZATION AND POLYMERS PRODUCED THEREFROM EXXONMOBIL CHEM PATENTS INC (US) 2011-08-10 EP disclosed
US-7294681-B2 Mutliple catalyst system for olefin polymerization and polymers produced therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-11-13 US disclosed
WO-2006091220-A1 HIGH IMPACT POLYMER COMPOSITIONS EXXONMOBIL CHEMICAL PATENTS INC. (US) 2006-08-31 WO disclosed
US-20050054781-A1 High impact polymer compositions EXXONMOBIL CHEMICAL PATENTS INC. 2005-03-10 US disclosed
WO-2004039852-A9 LOW DENSITY ETHYLENE COPOLYMER, A PROCESS FOR MAKING SAME AND BLENDS COMPRISING SUCH COPOLYMER EXXONMOBIL CHEM PATENTS INC (US) 2004-07-15 WO disclosed
WO-2004039852-A1 LOW DENSITY ETHYLENE COPOLYMER, A PROCESS FOR MAKING SAME AND BLENDS COMPRISING SUCH COPOLYMER EXXONMOBIL CHEMICAL PATENTS, INC. (US) 2004-05-13 WO disclosed