Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 6/20 | 0.40 |
| ▸ | CHRM3 known ✓ | P20309 | 6/20 | 0.40 |
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.40 |
| ▸ | ACHE known ✓ | P22303 | 5/20 | 0.36 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.36 |
| ▸ | BDKRB2 known ✓ | P30411 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 5/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28163699 | 0.93 | THRB (0.50) | THRBCHRM1CHRM3CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL543368 | 0.89 | THRB (0.50) | THRBCHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL1476595 | 0.88 | MEN1 (0.45) | THRBCHRM1CHRM3CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL166563 | 0.88 | MEN1 (0.45) | THRBCHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL1476296 | 0.88 | THRB (0.51) | THRBCHRM1CHRM3CHRM2CHRM4 | |
| Acrylamide SCHEMBL7755661 | 0.87 | MEN1 (0.39) | CHRM1CHRM3CHRM2CHRM4HTT | |
| Hydrochloric Acid SCHEMBL5183577 | 0.87 | THRB (0.47) | THRBCHRM1CHRM3CHRM2CHRM4 | |
| Bromide SCHEMBL2250534 | 0.87 | MEN1 (0.44) | THRBCHRM1CHRM3CHRM2CHRM4 | |
| Fluoride Ion SCHEMBL14815797 | 0.87 | MEN1 (0.44) | THRBCHRM1CHRM3CHRM2CHRM4 | |
| Iodide SCHEMBL2252213 | 0.87 | MEN1 (0.44) | THRBCHRM1CHRM3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11612898-B2 | Cationic polymer selective depressants and use thereof in mineral ore purification methods | KEMIRA OYJ (FI) | 2023-03-28 | — | — | US | disclosed |
| US-20190217311-A1 | CATIONIC POLYMER SELECTIVE DEPRESSANTS AND USE THEREOF IN MINERAL ORE PURIFICATION METHODS | KEMIRA OYJ (FI) | 2019-07-18 | — | — | US | disclosed |