Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | TAOK3 | Q9H2K8 | 2/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | ESRRG | P62508 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2113247 | 0.95 | CTSS (0.67) | CTSSHTR1AHTR2CDRD3TAOK3 | |
| SCHEMBL2115292 | 0.90 | CTSS (0.60) | CTSSESRRG | |
| SCHEMBL2726066 | 0.87 | CTSS (0.69) | CTSSHTR1AHTR2CDRD3TAOK3 | |
| SCHEMBL2113830 | 0.87 | CTSS (0.69) | CTSSHTR1AHTR2CDRD3TAOK3 | |
| SCHEMBL2726067 | 0.87 | CTSS (0.69) | CTSSHTR1AHTR2CDRD3TAOK3 | |
| SCHEMBL2112139 | 0.86 | CTSS (0.61) | CTSSHTR1ADRD3PPARA | |
| SCHEMBL2112569 | 0.85 | CTSS (0.66) | CTSSPPARA | |
| SCHEMBL2114505 | 0.83 | CTSS (0.65) | CTSSHTR1AHTR2CDRD3TAOK3 | |
| SCHEMBL2114397 | 0.83 | CTSS (0.73) | CTSSHTR1A | |
| SCHEMBL2618855 | 0.81 | CTSS (0.91) | CTSSHTR1AHTR2CDRD3TAOK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227468-B2 | Cathepsin S inhibitor compounds | ELI LILLY AND COMPANY (US) | 2012-07-24 | — | — | US | disclosed |
| US-20120095020-A1 | Cathepsin S Inhibitor Compounds | ELI LILLY AND COMPANY (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095020-A1 | Cathepsin S Inhibitor Compounds | CTSS, CTSZ, CTSV | CTSS 1/4885HTR1A 4170/4885HTR2C 4757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.