Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.66 |
| ▸ | RAB9A | P51151 | 6/20 | 0.66 |
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | HTR3A | P46098 | 4/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.66 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.66 |
| ▸ | RELA | Q04206 | 2/20 | 0.66 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.63 |
| ▸ | HTR3B | O95264 | 2/20 | 0.63 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17043892 | 0.98 | NPC1 (0.64) | NPC1RAB9AMAPTALDH1A1HTR3A | |
| Hydrochloric Acid SCHEMBL4056910 | 0.98 | NPC1 (0.64) | NPC1RAB9AMAPTALDH1A1HTR3A | |
| SCHEMBL6350588 | 0.94 | CHRNB2 (0.62) | NPC1RAB9AMAPTALDH1A1HTR3A | |
| SCHEMBL31753893 | 0.90 | NPC1 (0.58) | NPC1RAB9AMAPTALDH1A1HTR3A | |
| SCHEMBL31326693 | 0.89 | ALDH1A1 (0.55) | NPC1RAB9AMAPTALDH1A1HTR3A | |
| SCHEMBL29832295 | 0.84 | NPC1 (0.72) | NPC1RAB9AMAPTALDH1A1HTR3A | |
| SCHEMBL31184151 | 0.84 | NPC1 (0.72) | NPC1RAB9AMAPTALDH1A1HTR3A | |
| SCHEMBL1713999 | 0.82 | NPC1 (0.70) | NPC1RAB9AMAPTALDH1A1HTR3A | |
| SCHEMBL3552442 | 0.82 | NPC1 (0.70) | NPC1RAB9AMAPTALDH1A1HTR3A | |
| SCHEMBL3670386 | 0.81 | PLD1 (0.53) | NPC1RAB9AMAPTALDH1A1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220251049-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | NEUPHARMA, INC. | 2022-08-11 | — | — | US | disclosed |
| CN-103833658-B | BTA base piperazine compounds and its preparation method and pharmaceutical composition | 沈阳海王生物技术有限公司 | 2018-03-20 | — | — | CN | disclosed |
| EP-2867221-B1 | CYANOGUANIDINES AND THEIR SUE AS ANTIVIRAL AGENTS. | ABBVIE INC (US) | 2018-01-17 | — | — | EP | disclosed |
| CN-103833643-B | Benzimidazolyl piperazine compound and preparation method and pharmaceutical composition thereof | 沈阳海王生物技术有限公司 | 2018-01-02 | — | — | CN | disclosed |
| EP-3252045-A1 | CYANOGUANIDINES AND THEIR USE AS ANTIVIRAL AGENTS | AbbVie Inc. (US) | 2017-12-06 | — | — | EP | disclosed |
| US-9802929-B2 | Benzo five-membered nitrogen heterocyclic piperidine or piperazine derivatives and preparation methods and pharmaceutical compositions thereof | SHENYANG HAIWANG BIOTECHNOLOGY CO., LTD. (CN) | 2017-10-31 | — | — | US | disclosed |
| CN-106699670-A | Benzimidazolyl piperazine compounds, preparation method thereof and pharmaceutical composition | 辽宁艾美生物医药产业有限公司 | 2017-05-24 | — | — | CN | disclosed |
| US-9415047-B2 | Use of benzo five-membered nitrogen heterocyclic piperazine or piperidine derivatives | Liaoning Emmy Biological Pharmaceutical Co., Ltd. (CN) | 2016-08-16 | — | — | US | disclosed |
| US-20160009703-A1 | BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC PIPERIDINE OR PIPERAZINE DERIVATIVES AND PREPARATION METHODS AND PHARMACEUTICAL COMPOSITIONS THEREOF | LIAONING EMMY BIOLOGICAL PHARMACEUTICAL CO., LTD (CN) | 2016-01-14 | — | — | US | disclosed |
| US-20150297586-A1 | USE OF BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC PIPERAZINE OR PIPERIDINE DERIVATIVES | Liaoning Emmy Biological Pharmaceutical Co., Ltd. (CN) | 2015-10-22 | — | — | US | disclosed |
| US-4411904-A | Diphenylpropanamines, compositions thereof and use thereof | WARNER-LAMBERT COMPANY (US) | 1983-10-25 | — | — | US | disclosed |
| US-4376772-A | Use of piperazinyl-imidazo[1,2-a]pyrazines in sedation | MERCK & CO., INC. (US) | 1983-03-15 | — | — | US | disclosed |
| US-4364954-A | NEUROLEPTIC AGENT | WARNER-LAMBERT COMPANY (US) | 1982-12-21 | — | — | US | disclosed |
| EP-0065757-A1 | 1-(3-Halo-2-pyridinyl)piperazines, processes for their preparation and pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1982-12-01 | — | — | EP | disclosed |
| US-4302455-A | ANALGESICS, ANTIDEPRESSANTS | MERCK & CO., INC. (US) | 1981-11-24 | — | — | US | disclosed |
| US-4292321-A | 1,3,8-Triazaspirodecane-4-ones, pharmaceutical compositions thereof and method of use thereof | WARNER-LAMBERT COMPANY (US) | 1981-09-29 | — | — | US | disclosed |
| EP-0000121-A1 | 6-(1-Piperazinyl)-quinoxaline, process for its preparation and pharmaceutical compositions thereof | MERCK & CO. INC. (US) | 1979-01-10 | — | — | EP | disclosed |
| US-4091098-A | SEROTONINMIMETIC ACTIVITY; ANORECTIC, ANTIDEPRESSANT, ANALGESIC, HYPNOTIC AGENTS | MERCK & CO., INC. (US) | 1978-05-23 | — | — | US | disclosed |
| US-4091101-A | ANORECTIC AGENTS | MERCK & CO., INC. (US) | 1978-05-23 | — | — | US | disclosed |
| US-4082845-A | SEROTONINMIMETICS USEFUL AS ANORECTIC, ANTIDEPRESSANT, ANALGESIC AND HYPNOTIC AGENTS | MERCK & CO., INC. (US) | 1978-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220251049-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | BRAF, NRAS, KRAS | NPC1 4257/4885RAB9A 499/4885MAPT 3397/4885 |
| US-20150297586-A1 | USE OF BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC PIPERAZINE OR PIPERIDINE DERIVATIVES | P2RX5, TBXA2R, CYP3A5 | NPC1 1504/4885RAB9A 1784/4885MAPT 3556/4885 |
| US-20160009703-A1 | BENZO FIVE-MEMBERED NITROGEN HETEROCYCLIC PIPERIDINE OR PIPERAZINE DERIVATIVES AND PREPARATION METHODS AND PHARMACEUTICAL COMPOSITIONS THEREOF | CYP3A5, IL5, ABCC5 | NPC1 727/4885RAB9A 659/4885MAPT 3804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.