SCHEMBL21146819

SCHEMBL21146819

CC(C)c1ccc(-c2ccc(N(C)CCO)cc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.51
▸ SLC9A5 Q14940 1/20 0.43
▸ TRPV1 Q8NER1 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ KIF11 P52732 1/20 0.38
▸ FFAR1 O14842 1/20 0.36
▸ PTPN5 P54829 1/20 0.36
▸ EGFR P00533 1/20 0.35
▸ ERBB2 P04626 1/20 0.35
▸ NOX1 Q9Y5S8 1/20 0.35
▸ LMNA P02545 1/20 0.35
▸ TP53 P04637 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ ATM Q13315 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ NISCH Q9Y2I1 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6782387 0.94 L3MBTL1 (0.55) L3MBTL1SLC9A5TRPV1HPGDEGFR
SCHEMBL20004348 0.85 L3MBTL1 (0.48) L3MBTL1SLC9A5TRPV1HPGDKMT2A
SCHEMBL21146817 0.84 L3MBTL1 (0.45) L3MBTL1TRPV1HPGDEGFRERBB2
SCHEMBL21146821 0.82 APP (0.46) L3MBTL1KIF11PTPN5NISCH
SCHEMBL20004329 0.79 L3MBTL1 (0.44) L3MBTL1SLC9A5NOX1KMT2A
SCHEMBL25558319 0.79 MAPT (0.44) TRPV1KMT2A
SCHEMBL22537676 0.78 L3MBTL1 (0.43) L3MBTL1NOX1KMT2A
SCHEMBL11974254 0.77 NPSR1 (0.41) L3MBTL1HPGDEGFRERBB2KMT2A
SCHEMBL12648604 0.77 HPGD (0.42) L3MBTL1HPGDEGFRERBB2
SCHEMBL345445 0.77 EGFR (0.49) L3MBTL1HPGDEGFRERBB2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10906900-B2 Compounds for using in imaging and particularly for the diagnosis of neurodegenerative diseases CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2021-02-02 — — US disclosed
US-20190211011-A1 COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2019-07-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10906900-B2 Compounds for using in imaging and particularly for the diagnosis of neurodegenerative diseases PSEN2, CLN6, MAPT L3MBTL1 3895/4885SLC9A5 712/4885TRPV1 3371/4885
US-20190211011-A1 COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES PSEN2, SNCA, MAPT L3MBTL1 3949/4885SLC9A5 855/4885TRPV1 3572/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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