Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 9/20 | 0.48 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 3/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5073659 | 0.92 | APP (0.48) | POLBRAD52KMT2AAPPELANE | |
| SCHEMBL13968056 | 0.88 | KMT2A (0.66) | POLBRAD52KMT2AAPPPDE5A | |
| SCHEMBL29381485 | 0.85 | KMT2A (0.50) | POLBRAD52KMT2AAPPBCHE | |
| SCHEMBL21013099 | 0.85 | KMT2A (0.50) | POLBRAD52KMT2AAPPBCHE | |
| SCHEMBL28872741 | 0.85 | POLB (0.46) | POLBRAD52KMT2AAPPELANE | |
| SCHEMBL21632108 | 0.85 | BCHE (0.47) | POLBRAD52CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8121604 | 0.83 | KMT2A (0.55) | POLBRAD52KMT2AAPPPDE5A | |
| SCHEMBL17675656 | 0.82 | ACHE (0.52) | POLBRAD52ACHEBCHEKDM4E | |
| SCHEMBL213444 | 0.81 | APP (0.62) | POLBRAD52KMT2AAPPCYP1A2 | |
| SCHEMBL27744435 | 0.81 | KMT2A (0.42) | POLBRAD52KMT2AAPPELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11981670-B2 | Alkyl chain modified imidazoquinoline TLR7/8 agonist compounds and uses thereof | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2024-05-14 | — | — | US | disclosed |
| EP-4257198-A2 | ALKYL CHAIN MODIFIED IMIDAZOQUINOLINE DERIVATIVES AS TLR7/8 AGONISTS AND USES THEREOF | Dynavax Technologies Corporation (US) | 2023-10-11 | — | — | EP | disclosed |
| EP-3672969-B1 | ALKYL CHAIN MODIFIED IMIDAZOQUINOLINE DERIVATIVES AS TLR7/8 AGONISTS AND USES THEREOF | DYNAVAX TECH CORP (US) | 2023-07-05 | — | — | EP | disclosed |
| US-20220033400-A1 | ALKYL CHAIN MODIFIED IMIDAZOQUINOLINE TLR7/8 AGONIST COMPOUNDS AND USES THEREOF | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2022-02-03 | — | — | US | disclosed |
| US-11124510-B2 | Alkyl chain modified imidazoquinoline TLR7/8 agonist compounds and uses thereof | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2021-09-21 | — | — | US | disclosed |
| US-20210213010-A1 | TLR7/8 AGONISTS AND LIPOSOME COMPOSITIONS | DANMARKS TEKNISKE UNIVERSITET (DK) | 2021-07-15 | — | — | US | disclosed |
| EP-3827002-A1 | TLR7/8 AGONISTS AND LIPOSOME COMPOSITIONS | Torque Therapeutics, Inc. (US) | 2021-06-02 | — | — | EP | disclosed |
| EP-3710059-A1 | CLEAVABLE CONJUGATES OF TLR7/8 AGONIST COMPOUNDS, METHODS FOR PREPARATION, AND USES THEREOF | Dynavax Technologies Corporation (US) | 2020-09-23 | — | — | EP | disclosed |
| US-10722591-B2 | Cleavable conjugates of TLR7/8 agonist compounds, methods for preparation, and uses thereof | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2020-07-28 | — | — | US | disclosed |
| EP-3672969-A1 | ALKYL CHAIN MODIFIED IMIDAZOQUINOLINE TLR7/8 AGONIST COMPOUNDS AND USES THEREOF | Dynavax Technologies Corporation (US) | 2020-07-01 | — | — | EP | disclosed |
| EP-3356371-A1 | POLYMER CONJUGATE VACCINES | The University of Chicago (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-3215189-A1 | POLYMER ADJUVANT | Oxford University Innovation Limited (GB) | 2017-09-13 | — | — | EP | disclosed |
| WO-2016055812-A1 | POLYMER ADJUVANT | ISIS INNOVATION LIMITED (GB) | 2016-04-14 | — | — | WO | disclosed |
| EP-1948173-B1 | HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS | 3M INNOVATIVE PROPERTIES CO (US) | 2013-07-17 | — | — | EP | disclosed |
| US-8377957-B2 | Hydroxy and alkoxy substituted 1H-imidazoquinolines and methods | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2013-02-19 | — | — | US | disclosed |
| US-20120071463-A1 | HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS | 3M INNOVATIVE PROPERTIES COMPANY | 2012-03-22 | — | — | US | disclosed |
| US-8088790-B2 | Hydroxy and alkoxy substituted 1H-imidazoquinolines and methods | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2012-01-03 | — | — | US | disclosed |
| US-20090221556-A1 | HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS | PFIZER INC. | 2009-09-03 | — | — | US | disclosed |
| EP-1948173-A2 | HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS | Coley Pharmaceutical Group, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007056112-A2 | HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10722591-B2 | Cleavable conjugates of TLR7/8 agonist compounds, methods for preparation, and uses thereof | TLR7, TLR8, TLR9 | POLB 2215/4885RAD52 1106/4885KMT2A 1012/4885 |
| US-11981670-B2 | Alkyl chain modified imidazoquinoline TLR7/8 agonist compounds and uses thereof | TLR7, TLR8, TLR3 | POLB 2689/4885RAD52 3255/4885KMT2A 831/4885 |
| US-20210213010-A1 | TLR7/8 AGONISTS AND LIPOSOME COMPOSITIONS | TLR7, TLR9, TLR8 | POLB 4256/4885RAD52 4108/4885KMT2A 699/4885 |
| US-20090221556-A1 | HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS | IFNG, IL2, IRF3 | POLB 1616/4885RAD52 483/4885KMT2A 2108/4885 |
| US-11124510-B2 | Alkyl chain modified imidazoquinoline TLR7/8 agonist compounds and uses thereof | TLR7, TLR8, TLR3 | POLB 2689/4885RAD52 3255/4885KMT2A 831/4885 |
| US-20120071463-A1 | HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS | IFNG, IL2, IRF3 | POLB 1616/4885RAD52 483/4885KMT2A 2108/4885 |
| US-20220033400-A1 | ALKYL CHAIN MODIFIED IMIDAZOQUINOLINE TLR7/8 AGONIST COMPOUNDS AND USES THEREOF | TLR7, TLR8, TLR3 | POLB 2689/4885RAD52 3255/4885KMT2A 831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.