Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13208833 | 0.79 | MAOA (0.44) | MAOAMAOBHPGDERCC5FEN1 | |
| SCHEMBL533919 | 0.72 | SIGMAR1 (0.43) | MAOAMAOBHPGDERCC5FEN1 | |
| SCHEMBL23416547 | 0.72 | MAOA (0.37) | MAOAMAOBHPGDERCC5FEN1 | |
| SCHEMBL17319502 | 0.70 | ALDH1A1 (0.36) | HPGDNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20025577 | 0.69 | MAOA (0.44) | MAOAMAOBHPGDERCC5FEN1 | |
| SCHEMBL2992101 | 0.68 | MAOA (0.41) | MAOAMAOBHPGDERCC5FEN1 | |
| SCHEMBL2992104 | 0.68 | MAOA (0.41) | MAOAMAOBHPGDERCC5FEN1 | |
| SCHEMBL1128274 | 0.67 | HPGD (0.60) | MAOAMAOBHPGDERCC5FEN1 | |
| SCHEMBL3957272 | 0.67 | MAOA (0.47) | MAOAMAOBHPGDERCC5FEN1 | |
| SCHEMBL4749109 | 0.67 | MAOA (0.47) | MAOAMAOBHPGDERCC5FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2696878-B1 | DOSAGE REGIMEN FOR SAPACITABINE AND DECITABINE IN COMBINATION FOR TREATING ACUTE MYELOID LEUKEMIA | CYCLACEL LTD (GB) | 2019-07-10 | — | — | EP | disclosed |