Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 8/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.30 |
| ▸ | ITGAV | P06756 | 1/20 | 0.30 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.30 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.30 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21152695 | 0.97 | ESRRA (0.38) | ESRRAITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL21152666 | 0.94 | ESRRA (0.38) | ESRRA | |
| SCHEMBL21152628 | 0.94 | ESRRA (0.38) | ESRRA | |
| SCHEMBL21153288 | 0.91 | ESRRA (0.37) | ESRRA | |
| SCHEMBL25658857 | 0.86 | ESRRA (0.38) | ESRRA | |
| SCHEMBL21152646 | 0.84 | FOLH1 (0.35) | — | |
| SCHEMBL19983116 | 0.81 | MEN1 (0.34) | — | |
| SCHEMBL25658966 | 0.77 | TDP1 (0.39) | — | |
| SCHEMBL21152665 | 0.74 | ALB (0.39) | — | |
| SCHEMBL19983080 | 0.72 | CTSH (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230142714-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2023-05-11 | — | — | US | disclosed |
| US-20190210960-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230142714-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | PHYKPL, ENPEP, PREP | ESRRA 2729/4885ITGB3 3953/4885ITGB1 3353/4885 |
| US-20190210960-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | PHYKPL, ENPEP, PREP | ESRRA 2729/4885ITGB3 3953/4885ITGB1 3353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.