Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | DBH | P09172 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.35 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.35 |
| ▸ | CHRNG | P07510 | 4/20 | 0.35 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4246223 | 0.82 | PARP1 (0.46) | PARP1KDM4EALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL5423204 | 0.82 | PARP1 (0.49) | PARP1GAAALDH1A1NPSR1TDP1 | |
| SCHEMBL2282510 | 0.80 | KMO (0.56) | PARP1KDM4EGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL13962635 | 0.79 | PARP1 (0.46) | PARP1ALDH1A1SMN1; SMN2L3MBTL1KMO | |
| SCHEMBL13901589 | 0.79 | PARP1 (0.46) | PARP1ALDH1A1L3MBTL1KMONPC1 | |
| SCHEMBL6697278 | 0.79 | PARP1 (0.68) | PARP1RECQLTDP1L3MBTL1CYP2C19 | |
| SCHEMBL1417028 | 0.78 | RAB9A (0.49) | PARP1KDM4EGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL9430916 | 0.78 | ATM (0.46) | PARP1GAAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL2539492 | 0.78 | ATM (0.55) | PARP1KDM4EGAARECQLALDH1A1 | |
| SCHEMBL13414993 | 0.76 | SMN1; SMN2 (0.45) | PARP1ALDH1A1SMN1; SMN2TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210052519-A1 | Small molecule drugs and related methods for treatment of diseases related to tdo-43, alpha-synuclein, huntingtin's protein and tau protein oligomer formation | ACELOT,INC (US) | 2021-02-25 | — | — | US | disclosed |
| US-10703711-B2 | Small molecule drugs and related methods for treatment of diseases related to Aβ42 oligomer formation | ACELOT, INC. (US) | 2020-07-07 | — | — | US | disclosed |
| US-20190210959-A1 | Small molecule drugs and related methods for treatment of diseases related to abeta42 oligomer formation | ACELOT, INC. | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190210959-A1 | Small molecule drugs and related methods for treatment of diseases related to abeta42 oligomer formation | APP, PSEN2, PSEN1 | PARP1 3560/4885KDM4E 4863/4885DBH 730/4885 |
| US-10703711-B2 | Small molecule drugs and related methods for treatment of diseases related to Aβ42 oligomer formation | APP, PSEN2, PSEN1 | PARP1 2095/4885KDM4E 4816/4885DBH 1259/4885 |
| US-20210052519-A1 | Small molecule drugs and related methods for treatment of diseases related to tdo-43, alpha-synuclein, huntingtin's protein and tau protein oligomer formation | HTT, TARDBP, SNCA | PARP1 2991/4885KDM4E 4369/4885DBH 275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.