Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 12/20 | 0.38 |
| ▸ | ANPEP | P15144 | 7/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18403887 | 0.86 | HTRA1 (0.37) | NR1H2CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL21367042 | 0.85 | MMP2 (0.41) | MMP2ANPEPNR1H2NR1H3PTPN1 | |
| SCHEMBL2279591 | 0.85 | MMP2 (0.41) | MMP2ANPEPNR1H2NR1H3PTPN1 | |
| SCHEMBL12444959 | 0.83 | NR1H2 (0.42) | MMP2ANPEPNR1H2NR1H3PTPN1 | |
| SCHEMBL14393245 | 0.83 | NR1H2 (0.42) | MMP2ANPEPNR1H2NR1H3PTPN1 | |
| SCHEMBL4303999 | 0.83 | ALDH1A1 (0.43) | MMP2ANPEPNR1H2NR1H3PTPN1 | |
| SCHEMBL4304000 | 0.83 | ALDH1A1 (0.43) | MMP2ANPEPNR1H2NR1H3PTPN1 | |
| SCHEMBL7727315 | 0.82 | BTK (0.46) | MMP2ANPEPNR1H2NR1H3PTPN1 | |
| SCHEMBL7731684 | 0.82 | BTK (0.46) | MMP2ANPEPNR1H2NR1H3PTPN1 | |
| SCHEMBL13938226 | 0.82 | MMP2 (0.47) | MMP2ANPEPNR1H2NR1H3PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508482-A1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | Nanjing Transthera Biosciences Co. Ltd. (CN) | 2019-07-10 | — | — | EP | disclosed |