Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | QPCT | Q16769 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21154015 | 0.78 | MAPT (0.60) | ALDH1A1CYP2D6CYP2C19LMNAMAPT | |
| SCHEMBL13852158 | 0.76 | KCNH2 (0.40) | ALDH1A1CYP2D6CYP2C19LMNAMAPT | |
| SCHEMBL25911667 | 0.76 | LDHA (0.43) | ALDH1A1CYP2D6CYP2C19LMNAMAPT | |
| SCHEMBL21162587 | 0.75 | IKBKB (0.39) | ALDH1A1CYP2D6CYP2C19LMNAMAPT | |
| SCHEMBL22000881 | 0.75 | IDO1 (0.60) | ALDH1A1CYP2D6CYP2C19LMNAMAPT | |
| SCHEMBL2271723 | 0.73 | MAPK14 (0.43) | ALDH1A1LMNAMAPTKCNH2HRH3 | |
| SCHEMBL21154204 | 0.72 | RAB9A (0.57) | ALDH1A1CYP2D6CYP2C19LMNAMAPT | |
| SCHEMBL21588479 | 0.72 | SMN1; SMN2 (0.50) | ALDH1A1LMNAMAPTHSD17B10NPC1 | |
| Bromide SCHEMBL11217271 | 0.71 | MAPT (0.59) | ALDH1A1LMNAMAPTNPC1RAB9A | |
| SCHEMBL11207220 | 0.70 | NPC1 (0.67) | ALDH1A1CYP2D6CYP2C19LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019134978-A1 | 1, 3, 4, 5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE DERIVATIVES FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES LIKE ALZHEIMER'S DISEASE | AC IMMUNE SA (CH) | 2019-07-11 | — | — | WO | disclosed |