Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1066057 | 0.89 | CASP3 (0.40) | ALDH1A1CASP3SENP8SENP7SENP6 | |
| SCHEMBL1066058 | 0.88 | HTT (0.40) | ALDH1A1CASP3SENP8SENP7SENP6 | |
| SCHEMBL12933217 | 0.81 | BRD4 (0.36) | ALDH1A1CASP3SENP8SENP7SENP6 | |
| SCHEMBL24107506 | 0.78 | ALDH1A1 (0.44) | ALDH1A1CASP3SENP8SENP7SENP6 | |
| SCHEMBL10752180 | 0.78 | ALDH1A1 (0.49) | ALDH1A1CASP3SENP8SENP7SENP6 | |
| SCHEMBL23671634 | 0.77 | FDPS (0.40) | MAPTCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL30753861 | 0.76 | LATS1 (0.35) | ALDH1A1CASP3SENP8SENP7SENP6 | |
| SCHEMBL30753863 | 0.76 | MEN1 (0.41) | ALDH1A1MAPTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL30753862 | 0.76 | LATS1 (0.35) | ALDH1A1CASP3SENP8SENP7SENP6 | |
| SCHEMBL23671633 | 0.76 | FDPS (0.36) | ALDH1A1MAPTCYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019136112-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-07-11 | — | — | WO | disclosed |