Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19988679 | 0.92 | DYRK1A (0.42) | DYRK1ANPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL6031739 | 0.83 | NPC1 (0.46) | DYRK1ANPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL15689087 | 0.76 | DYRK1A (0.42) | DYRK1ANPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL22304452 | 0.76 | DYRK1A (0.42) | DYRK1ANPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL13166359 | 0.76 | DYRK1A (0.42) | DYRK1ANPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL4055332 | 0.76 | NPC1 (0.41) | DYRK1ANPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL4296143 | 0.75 | ALDH1A1 (0.52) | DYRK1ANPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL12228882 | 0.74 | DYRK1A (0.38) | DYRK1ANPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL1420652 | 0.73 | GAA (0.44) | DYRK1ANPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL4560336 | 0.73 | ALDH1A1 (0.50) | DYRK1ANPC1RAB9AL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512848-B1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | MERCK PATENT GMBH (DE) | 2020-11-18 | — | — | EP | disclosed |
| US-20190214574-A1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | MERCK PATENT GMBH (DE) | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190214574-A1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | CYCS, CYP3A4, CYP2E1 | DYRK1A 3310/4885NPC1 754/4885RAB9A 2257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.