Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 10/20 | 0.44 |
| ▸ | MAOB | P27338 | 10/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.34 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.34 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14059190 | 0.96 | MAPK1 (0.44) | MAPK1MEN1KMT2ANPSR1MAOA | |
| SCHEMBL16858594 | 0.93 | MAPK1 (0.49) | MAPK1MEN1KMT2ANPSR1MAOA | |
| SCHEMBL9245663 | 0.89 | HSD17B1 (0.44) | MAPK1MEN1KMT2ANPSR1MAOB | |
| SCHEMBL30042961 | 0.89 | HSD17B1 (0.44) | MAPK1MEN1KMT2ANPSR1MAOB | |
| SCHEMBL5372286 | 0.84 | MEN1 (0.55) | MAPK1MEN1KMT2ANPSR1MAOA | |
| SCHEMBL8615975 | 0.84 | MEN1 (0.55) | MAPK1MEN1KMT2ANPSR1MAOA | |
| SCHEMBL4808913 | 0.81 | HSD17B1 (0.44) | MAPK1MEN1KMT2ANPSR1MAOB | |
| SCHEMBL11460835 | 0.78 | MEN1 (0.49) | MAPK1MEN1KMT2ANPSR1MAOA | |
| SCHEMBL21155471 | 0.78 | MEN1 (0.49) | MAPK1MEN1KMT2ANPSR1MAOA | |
| SCHEMBL30888604 | 0.78 | MAOA (0.49) | MAPK1MEN1KMT2ANPSR1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116640156-A | RIPK1 inhibitors | 上海齐鲁制药研究中心有限公司 | 2023-08-25 | — | — | CN | disclosed |
| WO-2023119210-A1 | NOVEL COMPOUND AS RIPK1 INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | 제일약품주식회사 | 2023-06-29 | — | — | WO | disclosed |
| WO-2023119210-A1 | NOVEL COMPOUND AS RIPK1 INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | 제일약품주식회사 | 2023-06-29 | — | — | WO | disclosed |
| WO-2019134680-A1 | INHIBITOR OF APOPTOSIS SIGNAL-REGULATING KINASE-1 AND APPLICATION THEREOF | 广州市恒诺康医药科技有限公司 | 2019-07-11 | — | — | WO | disclosed |