Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 3/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23188915 | 0.84 | TSHR (0.45) | ALDH1A1TSHRLTA4HSMN1; SMN2LMNA | |
| SCHEMBL11310670 | 0.75 | ALDH1A1 (0.44) | ALDH1A1CYP3A4TSHREPHX2MEN1 | |
| SCHEMBL12591107 | 0.71 | CES2 (0.45) | ALDH1A1TSHREPHX2SMN1; SMN2LMNA | |
| SCHEMBL22710157 | 0.71 | ALDH1A1 (0.39) | ALDH1A1CYP3A4TSHRSMN1; SMN2LMNA | |
| SCHEMBL19980206 | 0.71 | TSHR (0.41) | ALDH1A1TSHREPHX2SMN1; SMN2LMNA | |
| SCHEMBL14336343 | 0.70 | LTA4H (0.48) | ALDH1A1CYP3A4TSHRLTA4HSMN1; SMN2 | |
| SCHEMBL7298648 | 0.70 | ALDH1A1 (0.44) | ALDH1A1TSHREPHX2SMN1; SMN2LMNA | |
| SCHEMBL13555325 | 0.70 | LTA4H (0.48) | ALDH1A1CYP3A4TSHRLTA4HSMN1; SMN2 | |
| SCHEMBL7298652 | 0.70 | ALDH1A1 (0.44) | ALDH1A1TSHREPHX2SMN1; SMN2LMNA | |
| SCHEMBL23188930 | 0.70 | TSHR (0.46) | ALDH1A1TSHRSMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508484-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-07-10 | — | — | EP | disclosed |