Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | BRS3 | P32247 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18675305 | 0.95 | ESR1 (0.38) | CYP11B1CYP11B2ESR1BRS3FDPS | |
| SCHEMBL18647609 | 0.84 | CYP11B1 (0.43) | CYP11B1CYP11B2FDPSCYP3A4ALDH1A1 | |
| SCHEMBL10223944 | 0.82 | ESR1 (0.45) | ESR1BRS3ALDH1A1 | |
| SCHEMBL20033692 | 0.82 | BRS3 (0.34) | CYP11B1CYP11B2BRS3FDPSCYP3A4 | |
| SCHEMBL21157383 | 0.80 | FDPS (0.35) | ESR1BRS3FDPSCYP3A4LOXL2 | |
| SCHEMBL19273974 | 0.78 | HRH3 (0.40) | CYP11B1CYP11B2ESR1BRS3CYP3A4 | |
| SCHEMBL22403759 | 0.76 | L3MBTL1 (0.41) | ESR1FDPSALDH1A1 | |
| SCHEMBL19383796 | 0.76 | CYP3A4 (0.41) | FDPSCYP3A4 | |
| SCHEMBL15342096 | 0.75 | HRH3 (0.47) | ESR1CYP3A4 | |
| SCHEMBL24919610 | 0.75 | LOXL2 (0.35) | CYP11B1CYP11B2ESR1FDPSCYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10968215-B2 | Pyrido five-element aromatic ring compound, preparation method therefor and use thereof | SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. (CN) | 2021-04-06 | — | — | US | disclosed |
| US-20190211010-A1 | PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | HAIHE BIOPHARMA CO. LTD. (CN) | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10968215-B2 | Pyrido five-element aromatic ring compound, preparation method therefor and use thereof | EZH2, IKZF2, SUZ12 | CYP11B1 373/4885CYP11B2 523/4885ESR1 1475/4885 |
| US-20190211010-A1 | PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | EZH2, IKZF2, SUZ12 | CYP11B1 373/4885CYP11B2 523/4885ESR1 1475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.