Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | CTRC | Q99895 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 2/20 | 0.34 |
| ▸ | EDNRA | P25101 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27818782 | 0.81 | TYR (0.37) | POLBTYRCYP2D6CTRCGAA | |
| SCHEMBL20344640 | 0.81 | ALOX15 (0.42) | TYRCTRCSMN1; SMN2HTTMEN1 | |
| SCHEMBL20344540 | 0.80 | TYR (0.41) | POLBTYRCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL21505455 | 0.78 | SKP2 (0.39) | POLBCYP1A2CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL14390806 | 0.77 | CYP3A4 (0.44) | POLBCYP2D6 | |
| SCHEMBL17376732 | 0.72 | ERN1 (0.42) | TYRCYP1A2CYP2D6CYP2C19CTRC | |
| SCHEMBL31108182 | 0.72 | TYR (0.46) | TYRCTRCLMNASMN1; SMN2NPC1 | |
| SCHEMBL22887810 | 0.72 | CTRC (0.37) | POLBTYRCTRCLMNASMN1; SMN2 | |
| SCHEMBL5536492 | 0.71 | LIPG (0.49) | — | |
| SCHEMBL1685968 | 0.71 | LIPG (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508484-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-07-10 | — | — | EP | disclosed |