Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 2/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2115701 | 1.00 | NCF1 (0.49) | NCF1PIK3CDPDE10AGBA1NPY5R | |
| SCHEMBL2115753 | 0.85 | AKT1 (0.41) | NCF1PIK3CDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL717258 | 0.82 | PIK3CD (0.53) | NCF1PIK3CDNPY5RALDH1A1TSHR | |
| SCHEMBL717259 | 0.82 | PIK3CD (0.53) | NCF1PIK3CDNPY5RALDH1A1TSHR | |
| SCHEMBL9165 | 0.81 | PIK3CD (0.44) | PIK3CDCYP2C9ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL715606 | 0.78 | CNR2 (0.41) | NCF1PIK3CDPDE10AALDH1A1KDM4E | |
| SCHEMBL715605 | 0.78 | CNR2 (0.41) | NCF1PIK3CDPDE10AALDH1A1KDM4E | |
| SCHEMBL2113480 | 0.77 | NCF1 (0.38) | NCF1PIK3CDGBA1SMO | |
| SCHEMBL2113484 | 0.77 | NCF1 (0.38) | NCF1PIK3CDGBA1SMO | |
| SCHEMBL2113713 | 0.76 | OPRK1 (0.38) | NCF1PIK3CDNPY5RALDH1A1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095005-A1 | Fused Bicyclic Pyrazole Derivatives As Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095005-A1 | Fused Bicyclic Pyrazole Derivatives As Kinase Inhibitors | PI4KA, PDPK1, PIK3CA | NCF1 2116/4885PIK3CD 6/4885PDE10A 1182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.