Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.57 |
| ▸ | ERN1 | O75460 | 7/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | BAD | Q92934 | 1/20 | 0.43 |
| ▸ | HNF4A | P41235 | 1/20 | 0.43 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
| ▸ | XDH | P47989 | 2/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591111 | 0.86 | ACMSD (0.59) | MCL1ERN1BCL2L1BADHNF4A | |
| SCHEMBL1795086 | 0.85 | SRC (0.56) | MCL1ERN1SMN1; SMN2SRCCSNK2A1 | |
| SCHEMBL25741026 | 0.80 | ERN1 (0.54) | ERN1 | |
| SCHEMBL16351974 | 0.80 | MCL1 (0.72) | MCL1AKR1C2AKR1C1SMN1; SMN2HNF4A | |
| SCHEMBL8840571 | 0.78 | MCL1 (0.65) | MCL1AKR1C2AKR1C1SMN1; SMN2HNF4A | |
| SCHEMBL12650689 | 0.78 | ERN1 (0.42) | MCL1ERN1BCL2L1BADHNF4A | |
| SCHEMBL5333100 | 0.77 | ERN1 (0.66) | MCL1ERN1 | |
| SCHEMBL28926892 | 0.76 | ERN1 (0.53) | MCL1ERN1HNF4AACMSD | |
| SCHEMBL10052771 | 0.75 | MCL1 (0.61) | MCL1AKR1C2AKR1C1SMN1; SMN2HNF4A | |
| SCHEMBL21857738 | 0.75 | PPM1B (0.67) | MCL1AKR1C2AKR1C1SMN1; SMN2HNF4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE47437-E1 | Prolyl hydroxylase inhibitors and methods of use | AKEBIA THERAPEUTICS, INC. (US) | 2019-06-18 | — | — | US | disclosed |