Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1B | O75688 | 1/20 | 0.67 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HNF4A | P41235 | 1/20 | 0.46 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23499274 | 0.90 | PPM1B (0.79) | PPM1BMCL1KDM4EKMT2AGFER | |
| SCHEMBL29908977 | 0.90 | PPM1B (0.79) | PPM1BMCL1KDM4EKMT2AGFER | |
| SCHEMBL29436316 | 0.88 | PPM1B (0.75) | PPM1BMCL1KDM4EKMT2AGFER | |
| SCHEMBL710309 | 0.88 | PPM1B (0.75) | PPM1BMCL1KDM4EKMT2AGFER | |
| SCHEMBL8898237 | 0.85 | KMT2A (0.78) | PPM1BMCL1KDM4EKMT2AGFER | |
| SCHEMBL30456877 | 0.85 | PPM1B (0.71) | PPM1BMCL1KDM4EKMT2AGFER | |
| SCHEMBL2575452 | 0.85 | PPM1B (0.71) | PPM1BMCL1KDM4EKMT2AGFER | |
| SCHEMBL283554 | 0.84 | CSNK2A1 (0.55) | PPM1BMCL1KDM4EKMT2AGFER | |
| SCHEMBL17177763 | 0.84 | PPM1B (0.70) | PPM1BMCL1KDM4EKMT2AGFER | |
| SCHEMBL29442128 | 0.84 | CSNK2A1 (0.55) | PPM1BMCL1KDM4EKMT2AGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020080979-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO DISCOVERY LIMITED LIABILITY COMPANY (RU) | 2020-04-23 | — | — | WO | disclosed |