Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2021947 | 0.84 | CYP1A2 (0.44) | CRHBPCRHR2SMN1; SMN2CYP1A2KMT2A | |
| SCHEMBL18398994 | 0.84 | CYP1A2 (0.60) | CRHBPCRHR2SMN1; SMN2CYP1A2KMT2A | |
| SCHEMBL10895337 | 0.81 | KMT2A (0.38) | CYP1A2KMT2ACYP2D6MAPTHRH4 | |
| SCHEMBL10896458 | 0.81 | KMT2A (0.38) | CYP1A2KMT2ACYP2D6MAPTHRH4 | |
| SCHEMBL2027503 | 0.81 | SORD (0.45) | SMN1; SMN2CYP1A2KMT2ACYP2D6MAPT | |
| SCHEMBL3413188 | 0.77 | KMT2A (0.53) | CRHBPCRHR2SMN1; SMN2CYP1A2KMT2A | |
| SCHEMBL27758019 | 0.77 | CASP1 (0.56) | KMT2AMAPTKDM4EGAAALDH1A1 | |
| SCHEMBL4116293 | 0.77 | CYP1A2 (0.48) | CRHBPCRHR2SMN1; SMN2CYP1A2KMT2A | |
| SCHEMBL3236763 | 0.77 | CYP1A2 (0.48) | CRHBPCRHR2SMN1; SMN2CYP1A2KMT2A | |
| SCHEMBL2020520 | 0.76 | KMT2A (0.38) | CRHBPCRHR2SMN1; SMN2CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3172211-B1 | TRICYCLIC IMIDAZO-PYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY LP-PLA2 | GLAXOSMITHKLINE IP DEV LTD (GB) | 2019-07-03 | — | — | EP | disclosed |