Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21157766 | 0.81 | CRHBP (0.42) | KMT2ACYP1A2CYP2D6MAPTHRH4 | |
| SCHEMBL10896206 | 0.79 | NUDT1 (0.35) | HRH4 | |
| SCHEMBL18398994 | 0.79 | CYP1A2 (0.60) | KMT2ACYP1A2CYP2D6MAPTLMNA | |
| SCHEMBL10896458 | 0.77 | KMT2A (0.38) | KMT2ACYP1A2CYP2D6MAPTLMNA | |
| SCHEMBL27758019 | 0.72 | CASP1 (0.56) | KMT2AMAPTLMNAMEN1 | |
| SCHEMBL16037441 | 0.71 | MAPT (0.55) | KMT2ACYP1A2CYP2D6MAPTHRH4 | |
| SCHEMBL10647429 | 0.71 | PDE10A (0.32) | — | |
| SCHEMBL3407486 | 0.71 | HRH4 (0.44) | KMT2AMAPTCNR2LMNAHRH4 | |
| SCHEMBL31541836 | 0.70 | ALDH1A1 (0.53) | KMT2ALMNAMEN1 | |
| SCHEMBL2021947 | 0.69 | CYP1A2 (0.44) | KMT2ACYP1A2CYP2D6MAPTHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4591588-A | Triazolo[1,5-c]pyrimidines and bronchodilation use thereof | RIKER LABORATORIES, INC. (US) | 1986-05-27 | — | — | US | disclosed |
| US-4536579-A | BRONCHODILATING AGENTS | RIKER LABORATORIES, INC. (US) | 1985-08-20 | — | — | US | disclosed |