⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12142226 | 0.85 | ATM (0.31) | — | |
| SCHEMBL19567290 | 0.79 | SPR (0.32) | — | |
| SCHEMBL24378705 | 0.79 | ATM (0.32) | — | |
| SCHEMBL20153208 | 0.76 | SPR (0.32) | — | |
| SCHEMBL21159146 | 0.76 | — | — | |
| SCHEMBL20070388 | 0.74 | — | — | |
| SCHEMBL20154515 | 0.73 | DRD2 (0.33) | — | |
| SCHEMBL18701955 | 0.73 | SPR (0.38) | — | |
| SCHEMBL18711896 | 0.72 | CHRNB2 (0.41) | — | |
| SCHEMBL22812219 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10953005-B1 | Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2021-03-23 | — | — | US | disclosed |
| US-10555944-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ELI LILLY AND COMPANY (US) | 2020-02-11 | — | — | US | disclosed |
| US-20190183886-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2019-06-20 | — | — | US | disclosed |