Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | PI4KA | P42356 | 1/20 | 0.45 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.45 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | TMIGD3 | P0DMS9 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1082007 | 0.95 | ADORA2A (0.61) | ADORA2ACYP1A2TSHRADORA1ADORA2B | |
| SCHEMBL2116000 | 0.83 | ADORA2A (0.64) | ADORA2ACYP1A2TSHRADORA1ADORA2B | |
| SCHEMBL22326754 | 0.82 | ADORA2A (0.69) | ADORA2ACYP1A2TSHRADORA1ADORA2B | |
| SCHEMBL8467559 | 0.81 | ADORA2A (0.60) | ADORA2ACYP1A2TSHRADORA1ADORA2B | |
| SCHEMBL31331791 | 0.81 | ADORA2A (0.68) | ADORA2ACYP1A2TSHRADORA1ADORA2B | |
| SCHEMBL8982987 | 0.81 | ADORA2A (0.68) | ADORA2ACYP1A2TSHRADORA1ADORA2B | |
| SCHEMBL1074972 | 0.81 | ADORA2A (1.00) | ADORA2ACYP1A2TSHRADORA1ADORA2B | |
| SCHEMBL11269779 | 0.80 | ADORA2A (0.66) | ADORA2ACYP1A2TSHRADORA1ADORA2B | |
| SCHEMBL11033550 | 0.78 | ADORA2A (0.45) | ADORA2ACYP1A2TSHRADORA1ADORA2B | |
| SCHEMBL14027563 | 0.78 | ADORA2A (0.59) | ADORA2ACYP1A2TSHRADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150119351-A1 | THERAPY OF TUMORS AND INFECTIOUS AGENTS DEFICIENT IN METHYLTHIOADENOSINE PHOSPHORYLASE | LUBIN ADAM (US) | 2015-04-30 | — | — | US | disclosed |
| US-8796241-B2 | Therapy of tumors and infectious agents deficient in methylthioadenosine phosphorylase | LUBIN ADAM (US) | 2014-08-05 | — | — | US | disclosed |
| US-20120094947-A1 | METHOD FOR THE SELECTIVE THERAPY OF DISEASE | LUBIN ADAM (US) | 2012-04-19 | — | — | US | disclosed |
| EP-2192905-A2 | METHOD FOR THE SELECTIVE THERAPY OF DISEASE | Lubin, Adam (US) | 2010-06-09 | — | — | EP | disclosed |
| WO-2009032057-A2 | METHOD FOR THE SELECTIVE THERAPY OF DISEASE | LUBIN ADAM (US) | 2009-03-12 | — | — | WO | disclosed |