Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.32 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21159595 | 0.85 | RAB9A (0.38) | HTTESR1ESR2LMNACSF1R | |
| SCHEMBL933733 | 0.68 | ESR1 (0.57) | ESR1ESR2AOC3IDO1LOXL2 | |
| SCHEMBL21159434 | 0.65 | MAP4K4 (0.34) | MAP4K4 | |
| SCHEMBL21090760 | 0.64 | NUDT1 (0.35) | HTTLMNA | |
| SCHEMBL15597723 | 0.62 | AOC3 (0.63) | ESR1ESR2AOC3IDO1LOXL2 | |
| SCHEMBL2316376 | 0.62 | CHEK1 (0.42) | LMNATP53 | |
| SCHEMBL10664748 | 0.61 | SMN1; SMN2 (0.42) | HTTLMNA | |
| SCHEMBL934572 | 0.61 | BCL2A1 (0.51) | ESR1ESR2AOC3LOXL2 | |
| SCHEMBL934617 | 0.61 | ESR1 (0.49) | ESR1ESR2AOC3LOXL2MAOB | |
| SCHEMBL3906522 | 0.60 | MPO (0.43) | IDO1LOXL2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3505171-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2019-07-03 | — | — | EP | disclosed |