Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.58 |
| ▸ | MYLK | Q15746 | 4/20 | 0.41 |
| ▸ | CDK4 | P11802 | 4/20 | 0.41 |
| ▸ | CCND1 | P24385 | 4/20 | 0.41 |
| ▸ | PRKACA | P17612 | 2/20 | 0.39 |
| ▸ | PRKACG | P22612 | 2/20 | 0.39 |
| ▸ | PRKACB | P22694 | 2/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | PRKCB | P05771 | 2/20 | 0.38 |
| ▸ | PRKCA | P17252 | 2/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | PRKCH | P24723 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21155204 | 0.87 | PARP1 (0.56) | PARP1CDK4CCND1PRKCBPRKCA | |
| SCHEMBL29435084 | 0.74 | PARP1 (1.00) | PARP1 | |
| SCHEMBL12256417 | 0.74 | PARP1 (1.00) | PARP1 | |
| SCHEMBL21160075 | 0.67 | PARP1 (0.38) | PARP1CDK4CCND1 | |
| SCHEMBL8112495 | 0.64 | CDK4 (0.72) | MYLKCDK4CCND1PRKACAPRKACG | |
| Hydrochloric Acid SCHEMBL30379478 | 0.63 | NQO2 (0.54) | PRKCBPRKCA | |
| SCHEMBL21160645 | 0.62 | PARP1 (0.74) | PARP1 | |
| SCHEMBL8122531 | 0.60 | MYLK (0.72) | MYLKCDK4CCND1PRKACAPRKACG | |
| SCHEMBL21155625 | 0.60 | PARP1 (0.70) | PARP1 | |
| SCHEMBL8121899 | 0.60 | MYLK (0.68) | MYLKCDK4CCND1PRKACAPRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019136298-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATMENT OF DISEASES INVOLVING ACIDIC OR HYPOXIC DISEASED TISSUES | Cybrexa, Inc. (US) | 2019-07-11 | — | — | WO | disclosed |