Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.58 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947467 | 0.84 | TBXAS1 (0.54) | NR4A2RAB9ANPC1ALDH1A1GAA | |
| SCHEMBL1557011 | 0.81 | FFAR1 (0.71) | EGFRNR4A1NR4A2NR4A3MAOB | |
| SCHEMBL8637323 | 0.80 | TAAR1 (0.53) | MAOBRAB9ANPC1GAAMAPT | |
| SCHEMBL8307657 | 0.78 | LTA4H (0.56) | ALOX5FFAR1FFAR4 | |
| SCHEMBL22664707 | 0.77 | FFAR1 (0.74) | EGFRNR4A1NR4A2NR4A3MAOB | |
| SCHEMBL11473805 | 0.77 | SMN1; SMN2 (0.51) | RAB9ANPC1ALDH1A1SMN1; SMN2CES1 | |
| SCHEMBL11702882 | 0.76 | TAAR1 (0.73) | MAOBRAB9ANPC1GAAMAPT | |
| SCHEMBL6811506 | 0.76 | EGFR (0.69) | EGFRNR4A1NR4A2NR4A3MAOB | |
| SCHEMBL958582 | 0.76 | EGFR (0.69) | EGFRNR4A1NR4A2NR4A3MAOB | |
| SCHEMBL11264743 | 0.74 | TAAR1 (0.56) | FFAR1ALDH1A1GAASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10344001-B2 | Azolylacryloyl derivatives as therapeutic agents for sickle cell disease | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2019-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10344001-B2 | Azolylacryloyl derivatives as therapeutic agents for sickle cell disease | HBG1, HIF1AN, TNNI3 | EGFR 4762/4885NR4A1 4451/4885NR4A2 4114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.