Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 3/20 | 0.39 |
| ▸ | PREP | P48147 | 2/20 | 0.39 |
| ▸ | FAP | Q12884 | 2/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24456666 | 0.92 | POLB (0.47) | ALDH1A1TSHRGAAPOLBL3MBTL1 | |
| SCHEMBL24456752 | 0.92 | POLB (0.47) | ALDH1A1TSHRGAAPOLBL3MBTL1 | |
| SCHEMBL14327358 | 0.81 | ALDH1A1 (0.44) | ALDH1A1TSHRGAAPOLBL3MBTL1 | |
| SCHEMBL30665025 | 0.80 | KMT2A (0.51) | ALDH1A1TSHRGAAL3MBTL1HSD11B1 | |
| SCHEMBL3335647 | 0.79 | POLB (0.48) | POLBL3MBTL1DPP4PREPFAP | |
| SCHEMBL1597059 | 0.79 | POLB (0.48) | POLBL3MBTL1DPP4PREPFAP | |
| SCHEMBL1597060 | 0.79 | POLB (0.48) | POLBL3MBTL1DPP4PREPFAP | |
| SCHEMBL13003862 | 0.77 | POLB (0.47) | POLBL3MBTL1DPP4PREPFAP | |
| SCHEMBL2341978 | 0.77 | POLB (0.47) | POLBL3MBTL1DPP4PREPFAP | |
| Hydrochloric Acid SCHEMBL11896218 | 0.77 | POLB (0.47) | POLBL3MBTL1DPP4PREPFAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906553-B1 | OREXIN RECEPTOR ANTAGONISTS WHICH ARE [ORTHO BI (HETERO )ARYL]-[2-(META BI (HETERO)ARYL)-PYRROLIDIN-1-YL]-METHANONE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-06-26 | — | — | EP | disclosed |