Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 5/20 | 0.41 |
| ▸ | FAP | Q12884 | 3/20 | 0.41 |
| ▸ | PREP | P48147 | 2/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24456666 | 1.00 | POLB (0.47) | POLBL3MBTL1HPGDMAPTDPP4 | |
| SCHEMBL21163185 | 0.92 | ALDH1A1 (0.48) | POLBL3MBTL1HPGDDPP4FAP | |
| SCHEMBL20713023 | 0.82 | MAPT (0.46) | POLBL3MBTL1HPGDMAPTGAA | |
| SCHEMBL1597060 | 0.82 | POLB (0.48) | POLBL3MBTL1MAPTDPP4FAP | |
| SCHEMBL3335647 | 0.82 | POLB (0.48) | POLBL3MBTL1MAPTDPP4FAP | |
| SCHEMBL1597059 | 0.82 | POLB (0.48) | POLBL3MBTL1MAPTDPP4FAP | |
| SCHEMBL12825153 | 0.80 | POLB (0.58) | POLBL3MBTL1HPGDMAPTDPP4 | |
| Hydrochloric Acid SCHEMBL11896218 | 0.80 | POLB (0.47) | POLBL3MBTL1MAPTDPP4FAP | |
| SCHEMBL13003862 | 0.80 | POLB (0.47) | POLBL3MBTL1DPP4FAPPREP | |
| Hydrochloric Acid SCHEMBL11895384 | 0.80 | POLB (0.47) | POLBL3MBTL1MAPTDPP4FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109492-A1 | PYRROLOPYRIDAZINE COMPOUNDS AS KINASE INHIBITORS | GOSSAMER BIOSERVICES, INC. (US) | 2022-05-27 | — | — | WO | disclosed |
| WO-2022109492-A1 | PYRROLOPYRIDAZINE COMPOUNDS AS KINASE INHIBITORS | GOSSAMER BIOSERVICES, INC. (US) | 2022-05-27 | — | — | WO | disclosed |