Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21163196 | 0.91 | ALDH1A1 (0.44) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL17069024 | 0.83 | EPHX2 (0.53) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL14072034 | 0.82 | ALDH1A1 (0.47) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL18136590 | 0.81 | EPHX2 (0.55) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL21163198 | 0.81 | GRM5 (0.47) | S1PR3 | |
| SCHEMBL6295559 | 0.80 | ALDH1A1 (0.47) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL8121446 | 0.79 | CHRNB2 (0.56) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL8114296 | 0.79 | CHRNB2 (0.56) | ALDH1A1TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL21065089 | 0.79 | HCRTR1 (0.57) | ALDH1A1TSHRUSP30NPSR1LMNA | |
| SCHEMBL21065088 | 0.79 | HCRTR1 (0.57) | ALDH1A1TSHRUSP30NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906553-B1 | OREXIN RECEPTOR ANTAGONISTS WHICH ARE [ORTHO BI (HETERO )ARYL]-[2-(META BI (HETERO)ARYL)-PYRROLIDIN-1-YL]-METHANONE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-06-26 | — | — | EP | disclosed |