Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 6/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21163197 | 0.91 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2AL3MBTL1TSHR | |
| SCHEMBL8114296 | 0.83 | CHRNB2 (0.56) | ALDH1A1MEN1KMT2AL3MBTL1TSHR | |
| SCHEMBL8121446 | 0.83 | CHRNB2 (0.56) | ALDH1A1MEN1KMT2AL3MBTL1TSHR | |
| SCHEMBL9254476 | 0.82 | CHRNB2 (0.51) | ALDH1A1MEN1KMT2AL3MBTL1TSHR | |
| SCHEMBL9264718 | 0.82 | SCD5 (0.49) | ALDH1A1MEN1KMT2AL3MBTL1TSHR | |
| SCHEMBL9264284 | 0.81 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AL3MBTL1TSHR | |
| SCHEMBL8121245 | 0.81 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AL3MBTL1TSHR | |
| SCHEMBL8139425 | 0.81 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AL3MBTL1TSHR | |
| SCHEMBL21163195 | 0.81 | GRM5 (0.47) | — | |
| SCHEMBL21065088 | 0.81 | HCRTR1 (0.57) | ALDH1A1TSHRUSP30LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906553-B1 | OREXIN RECEPTOR ANTAGONISTS WHICH ARE [ORTHO BI (HETERO )ARYL]-[2-(META BI (HETERO)ARYL)-PYRROLIDIN-1-YL]-METHANONE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-06-26 | — | — | EP | disclosed |