Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.67 |
| ▸ | MAPT | P10636 | 8/20 | 0.67 |
| ▸ | MEN1 | O00255 | 7/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.67 |
| ▸ | GAA | P10253 | 4/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.64 |
| ▸ | DUSP3 | P51452 | 6/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | HPGD | P15428 | 7/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11450570 | 0.81 | MAPT (0.74) | KDM4EMAPTMEN1KMT2AGAA | |
| SCHEMBL24928789 | 0.80 | MAPT (0.58) | KDM4EMAPTMEN1KMT2AGAA | |
| SCHEMBL2136353 | 0.80 | MAPT (1.00) | KDM4EMAPTMEN1KMT2AGAA | |
| SCHEMBL27819183 | 0.78 | CASP3 (0.46) | KDM4EMAPTMEN1KMT2AGAA | |
| SCHEMBL20660046 | 0.78 | DYRK1A (0.80) | KDM4EMAPTMEN1KMT2AGAA | |
| SCHEMBL3047328 | 0.78 | DYRK1A (0.80) | KDM4EMAPTMEN1KMT2AGAA | |
| SCHEMBL15376502 | 0.78 | DYRK1A (1.00) | KDM4EMAPTMEN1KMT2AGAA | |
| SCHEMBL3050805 | 0.77 | DYRK1A (0.78) | KDM4EMAPTMEN1KMT2AGAA | |
| SCHEMBL3254919 | 0.77 | ALDH1A1 (0.59) | KDM4EMAPTMEN1KMT2AGAA | |
| SCHEMBL20659925 | 0.76 | DYRK1A (0.76) | KDM4EMAPTMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |