SCHEMBL2136353

SCHEMBL2136353

COc1cccc2sc(NN)nc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 1.00
MEN1 O00255 8/20 1.00
KMT2A Q03164 8/20 1.00
KDM4E B2RXH2 6/20 1.00
GAA P10253 6/20 1.00
ALDH1A1 P00352 8/20 0.71
TDP1 Q9NUW8 7/20 0.71
MAPK1 P28482 4/20 0.71
PKM P14618 2/20 0.71
DYRK1A Q13627 1/20 0.65
CYP3A4 P08684 1/20 0.64
LMNA P02545 6/20 0.59
HPGD P15428 5/20 0.59
DUSP3 P51452 3/20 0.56
CHRM4 P08173 1/20 0.56
RAB9A P51151 4/20 0.55
SMN1; SMN2 Q16637 4/20 0.55
NPC1 O15118 3/20 0.55
AGTR1 P30556 1/20 0.55
NPSR1 Q6W5P4 3/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
(Phenylsulfonyl)Benzene SCHEMBL28531281 0.87 MAPT (0.76) MAPTMEN1KMT2AKDM4EGAA
SCHEMBL28531283 0.87 MAPT (0.76) MAPTMEN1KMT2AKDM4EGAA
SCHEMBL11450570 0.85 MAPT (0.74) MAPTMEN1KMT2AKDM4EGAA
SCHEMBL2136477 0.83 MAPT (1.00) MAPTMEN1KMT2AKDM4EGAA
SCHEMBL20659925 0.83 DYRK1A (0.76) MAPTMEN1KMT2AKDM4EGAA
Hydrazine SCHEMBL20659924 0.82 DYRK1A (0.74) MAPTMEN1KMT2AKDM4EGAA
SCHEMBL3050805 0.81 DYRK1A (0.78) MAPTMEN1KMT2AKDM4EGAA
SCHEMBL211638 0.80 KDM4E (0.67) MAPTMEN1KMT2AKDM4EGAA
SCHEMBL25321763 0.80 MAPT (0.66) MAPTMEN1KMT2AKDM4EGAA
SCHEMBL3072555 0.80 ALDH1A1 (0.67) MAPTMEN1KMT2AKDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3990569-B1 NEW POLYMERIZABLE LIQUID CRYSTAL ROLIC TECH AG (CH) 2024-12-04 EP disclosed
CN-118702646-A Novel polymerizable liquid crystal 罗利克技术有限公司 2024-09-27 CN disclosed
CN-114026078-B Novel polymerizable liquid crystal 罗利克技术有限公司 2024-06-07 CN disclosed
EP-3990569-A1 NEW POLYMERIZABLE LIQUID CRYSTAL Rolic Technologies AG (CH) 2022-05-04 EP disclosed
CN-112574077-B Method for synthesizing sulfone compound under photocatalysis condition 河南大学 2022-02-22 CN disclosed
CN-114026078-A Novel polymerizable liquid crystal 罗利克技术有限公司 2022-02-08 CN disclosed
CN-112574077-A Method for synthesizing sulfone compound under photocatalysis condition 河南大学 2021-03-30 CN disclosed
US-20200283399-A1 METHOD OF PRODUCING POLYMERIZABLE COMPOUND, AND SOLUTION OF POLYMERIZABLE COMPOUND ZEON CORPORATION (JP) 2020-09-10 US disclosed
US-20200190077-A1 NEUROPROTECTIVE HYDRAZIDES DAHL RUSSELL (US) 2020-06-18 US disclosed
EP-3604289-A1 POLYMERIZABLE COMPOUND PRODUCTION METHOD AND POLYMERIZABLE COMPOUND SOLUTION Zeon Corporation (JP) 2020-02-05 EP disclosed
US-20190322936-A1 POLYMERIZABLE COMPOUND, POLYMERIZABLE LIQUID CRYSTAL MIXTURE, POLYMER, OPTICAL FILM, OPTICALLY ANISOTROPIC BODY, POLARIZER, DISPLAY, ANTIREFLECTION FILM, AND COMPOUND ZEON CORPORATION (JP) 2019-10-24 US disclosed
US-20190322872-A1 POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, OPTICAL FILM, OPTICALLY ANISOTROPIC BODY, POLARIZER, FLAT PANEL DISPLAY, ORGANIC ELECTROLUMINESCENCE DISPLAY, ANTIREFLECTION FILM, AND COMPOUND ZEON CORPORATION (JP) 2019-10-24 US disclosed
US-8242278-B2 Process for producing biaryl compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-08-14 US disclosed
US-20120101278-A1 PROCESS FOR PRODUCING BIARYL COMPOUND HAGIYA KOJI (JP) 2012-04-26 US disclosed
EP-1473286-B1 PROCESS FOR PRODUCING BIARYL COMPOUND SUMITOMO CHEMICAL CO (JP) 2009-11-04 EP disclosed
US-20090216017-A1 PROCESS FOR PRODUCING BIARYL COMPOUND HAGIYA KOJI 2009-08-27 US disclosed
US-7554000-B2 Process for producing biaryl compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-06-30 US disclosed
US-20050096471-A1 Process for producing biaryl compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-05-05 US disclosed
EP-1473286-A1 PROCESS FOR PRODUCING BIARYL COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-03 EP disclosed
US-3937714-A 2-AMINOBENZOTHIAZOLES, HYDRAZINE, ACID CATALYSTS ELI LILLY AND COMPANY (US) 1976-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190322872-A1 POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, OPTICAL FILM, OPTICALLY ANISOTROPIC BODY, POLARIZER, FLAT PANEL DISPLAY, ORGANIC ELECTROLUMINESCENCE DISPLAY, ANTIREFLECTION FILM, AND COMPOUND H1-0, H1-4, H1-10 MAPT 1740/4885MEN1 2112/4885KMT2A 2948/4885
US-20120101278-A1 PROCESS FOR PRODUCING BIARYL COMPOUND PPOX, CAT, TYR MAPT 3403/4885MEN1 3325/4885KMT2A 575/4885
US-20090216017-A1 PROCESS FOR PRODUCING BIARYL COMPOUND PPOX, CAT, TYR MAPT 3403/4885MEN1 3325/4885KMT2A 575/4885
US-20200190077-A1 NEUROPROTECTIVE HYDRAZIDES PINK1, UCHL1, SIRT1 MAPT 387/4885MEN1 4692/4885KMT2A 2474/4885
US-20200283399-A1 METHOD OF PRODUCING POLYMERIZABLE COMPOUND, AND SOLUTION OF POLYMERIZABLE COMPOUND PDE8A, ADCY6, TKFC MAPT 1337/4885MEN1 326/4885KMT2A 3209/4885
US-20050096471-A1 Process for producing biaryl compound PPOX, CAT, TYR MAPT 3403/4885MEN1 3325/4885KMT2A 575/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.