Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.55 |
| ▸ | HPGD | P15428 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | USP14 | P54578 | 9/20 | 0.50 |
| ▸ | USP7 | Q93009 | 3/20 | 0.50 |
| ▸ | USP5 | P45974 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19501354 | 0.91 | SMN1; SMN2 (0.63) | SMN1; SMN2HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL23559409 | 0.89 | USP14 (0.65) | SMN1; SMN2HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL17949745 | 0.89 | USP14 (0.65) | SMN1; SMN2HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL6921750 | 0.89 | SMN1; SMN2 (0.55) | SMN1; SMN2HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL19749203 | 0.87 | USP14 (0.50) | SMN1; SMN2HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL23524575 | 0.82 | SMN1; SMN2 (0.63) | SMN1; SMN2HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL19749200 | 0.80 | USP14 (0.49) | SMN1; SMN2HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL6922448 | 0.79 | SMN1; SMN2 (0.81) | SMN1; SMN2HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL23524513 | 0.79 | SMN1; SMN2 (0.58) | SMN1; SMN2HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL19501866 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2HPGDNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10351568-B2 | Compositions and methods for enhancing proteasome activity | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10351568-B2 | Compositions and methods for enhancing proteasome activity | PSMG3, PSME3, PSMB11 | SMN1; SMN2 307/4885HPGD 4170/4885NPC1 2643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.