Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP14 | P54578 | 5/20 | 0.65 |
| ▸ | USP7 | Q93009 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.63 |
| ▸ | HPGD | P15428 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | USP5 | P45974 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17949745 | 1.00 | USP14 (0.65) | USP14USP7SMN1; SMN2HPGDNPC1 | |
| SCHEMBL23524575 | 0.94 | SMN1; SMN2 (0.63) | USP14USP7SMN1; SMN2HPGDNPC1 | |
| SCHEMBL19501354 | 0.91 | SMN1; SMN2 (0.63) | USP14USP7SMN1; SMN2HPGDNPC1 | |
| SCHEMBL23524513 | 0.90 | SMN1; SMN2 (0.58) | USP14USP7SMN1; SMN2HPGDNPC1 | |
| SCHEMBL6921750 | 0.89 | SMN1; SMN2 (0.55) | USP14USP7SMN1; SMN2HPGDNPC1 | |
| SCHEMBL21165025 | 0.89 | SMN1; SMN2 (0.55) | USP14USP7SMN1; SMN2HPGDNPC1 | |
| SCHEMBL17949715 | 0.87 | SMN1; SMN2 (0.55) | USP14USP7SMN1; SMN2HPGDNPC1 | |
| SCHEMBL23559530 | 0.85 | USP14 (0.57) | USP14USP7SMN1; SMN2HPGDNPC1 | |
| SCHEMBL23559456 | 0.85 | USP14 (0.57) | USP14USP7SMN1; SMN2HPGDNPC1 | |
| SCHEMBL23559457 | 0.85 | USP14 (0.57) | USP14USP7SMN1; SMN2HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240116894-A1 | PROTEASOME ACTIVITY ENHANCING COMPOUNDS | Kineta, Inc. | 2024-04-11 | — | — | US | disclosed |
| US-11746098-B2 | Proteasome activity enhancing compounds | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2023-09-05 | — | — | US | disclosed |
| US-11746098-B2 | Proteasome activity enhancing compounds | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2023-09-05 | — | — | US | disclosed |
| US-20210188802-A1 | PROTEASOME ACTIVITY ENHANCING COMPOUNDS | PROTEOSTASIS THERAPEUTICS, INC. | 2021-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11746098-B2 | Proteasome activity enhancing compounds | PSMG3, PSMC1, PSMB11 | USP14 7/4885USP7 40/4885SMN1; SMN2 819/4885 |
| US-20210188802-A1 | PROTEASOME ACTIVITY ENHANCING COMPOUNDS | PSMG3, PSMC1, PSMB11 | USP14 7/4885USP7 40/4885SMN1; SMN2 819/4885 |
| US-20240116894-A1 | PROTEASOME ACTIVITY ENHANCING COMPOUNDS | PSMG3, PSMC1, PSMB11 | USP14 7/4885USP7 40/4885SMN1; SMN2 819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.