Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | USP14 | P54578 | 3/20 | 0.42 |
| ▸ | USP7 | Q93009 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | USP5 | P45974 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921452 | 0.86 | USP14 (0.56) | HPGDKDM4EUSP14USP7SMN1; SMN2 | |
| SCHEMBL19501173 | 0.86 | SMN1; SMN2 (0.53) | HPGDKDM4EUSP14USP7SMN1; SMN2 | |
| SCHEMBL19749177 | 0.77 | GAA (0.46) | HPGDKDM4ESMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL23559540 | 0.76 | SMN1; SMN2 (0.49) | HPGDKDM4EUSP14USP7SMN1; SMN2 | |
| SCHEMBL21165030 | 0.76 | NOTUM (0.48) | HPGDUSP14USP7SMN1; SMN2ALDH1A1 | |
| SCHEMBL23559501 | 0.75 | SMN1; SMN2 (0.48) | HPGDKDM4EUSP14USP7SMN1; SMN2 | |
| SCHEMBL21165185 | 0.74 | KDM4E (0.40) | HPGDKDM4EUSP14USP7SMN1; SMN2 | |
| SCHEMBL6922703 | 0.74 | USP14 (0.76) | HPGDKDM4EUSP14USP7SMN1; SMN2 | |
| SCHEMBL23524472 | 0.73 | SMN1; SMN2 (0.77) | HPGDKDM4EUSP14USP7SMN1; SMN2 | |
| SCHEMBL10476938 | 0.66 | UGCG (0.50) | KDM4EALDH1A1MAPK1KMT2AOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10351568-B2 | Compositions and methods for enhancing proteasome activity | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10351568-B2 | Compositions and methods for enhancing proteasome activity | PSMG3, PSME3, PSMB11 | HPGD 4170/4885KDM4E 2300/4885USP14 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.